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Principles of Nuclear Magnetic Resonance Microscopy Paul Callaghan
Publisher: Oxford University Press, USA

Multivariate techniques such as principle component analysis (PCA) and linear discriminant analysis (LDA) can be used to analyse these metabolite concentrations with the goal of improving tumour characterisation and classification [26,27]. Texas A&M University's Department of Biochemistry and Biophysics received a Nuclear Magnetic Resonance spectrometer that will expand macromolecular research. Many have taken an X-ray, CT scan or MRI at a hospital to diagnose a broken leg, but the same principle can be used to get a close-up view of individual molecules. Magnetic resonance microscopy: recent advances and applications. The resulting response by the total magnetization (M) of the nuclear spins is the phenomenon that is exploited in NMR spectroscopy and magnetic resonance imaging. 1H magic angle spinning NMR spectroscopy (1H HR-MAS) is a powerful tool for determining metabolite profiles from small pieces of intact tissue and could potentially provide important molecular information. The resulting response to the perturbing magnetic field is the phenomenon that is exploited in NMR spectroscopy and magnetic resonance imaging, which use very powerful applied magnetic fields in order to achieve high resolution spectra, details of which are described by the chemical shift and the Zeeman effect. However, a proton and neutron will have lower energy when their spins are parallel, not anti-parallel, as this parallel spin alignment does not infringe upon the Pauli principle, but instead has to do with the quark structure of "Magnetic resonance microscopy: recent advances and applications". An NMR spectrometer works similarly to an MRI, but on a microscopic level. €�An MRI places the whole organism in the magnetic field. NMR phenomena instead of nuclei. The basic principles are otherwise similar.